HORDB

ID: hor002180
Uniprot ID: P21563
Protein name: Insulin A chain
Gene name: INS
Organism: Rodentia sp
Family: Insulin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: unclassified Rodentia, Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0005975 carbohydrate metabolic process; GO:0006006 glucose metabolic process; GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Sequence: IVQQCTSGICSLYQENYCN
Length: 19
Propeptide: MALWILLPLLALLILWGPDPAQAFVNQHLCGSHLVEALYILVCGERGFFYTPMSRREVEDPQVGQVELGAGPGAGSEQTLALEVARQARIVQQCTSGICSLYQENYCN
Signal peptide: MALWILLPLLALLILWGPDPAQA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002180_AF2.pdb

hor002180_ESM.pdb

Mass:	248768	Formula:	C90H140N24O32S3
Absent amino acids:	ADFHKMPRW	Common amino acids:	CQ
pI:	3.85	Basic residues:	0
Polar residues:	11	Hydrophobic residues:	4
Hydrophobicity:	-9.47	Boman Index:	-2278
Half-Life:	20 hour	Half-Life Yeast:	30 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	76.84
Instability Index:	3400	Extinction Coefficient cystines:	3105
Absorbance 280nm:	172.5